Feridex I.V.

DRUG DESCRIPTION

Feridex I.V.® (ferumoxides injectable solution) is a sterile
aqueous colloid of superparamagnetic iron oxide associated with dextran for
intravenous (i.v.) administration as a magnetic resonance imaging contrast
media. Chemically, ferumoxides is a non-stoichiometric magnetite, of average
formula FeO1.44. Each milliliter of Feridex I.V. (ferumoxides injectable solution) contains 11.2 milligrams of
iron and 61.3 milligrams of mannitol at a pH of 5 to 9. The formulation also
contains dextran (5.6–9.1 mg/mL) and citrate (0.25–0.53 mg/mL).

The osmolality is approximately 340 mOsm/kg; specific
gravity is 1.04. Feridex I.V. (ferumoxides injectable solution) is a black to reddish-brown aqueous colloid.